Segregated responses of mammary gland development and vaginal opening to prepubertal genistein exposure in Bscl2−/− female mice with lipodystrophy
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Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring.
Perfluorooctanoic acid (PFOA), with diverse and widespread commercial and industrial applications, has been detected in human and wildlife sera. Previous mouse studies linked prenatal PFOA exposure to decreased neonatal body weights (BWs) and survival in a dose-dependent manner. To determine whether effects were linked to gestational time of exposure or to subsequent lactational changes, timed-...
متن کاملNeonatal exposure to daidzein, genistein, or the combination modulates bone development in female CD-1 mice.
Neonatal exposure to genistein (GEN), an isoflavone abundant in soy, favorably modulates bone mineral density (BMD) and bone strength in mice at adulthood. The study objective was to determine whether early exposure to a combination of the soy isoflavones daidzein (DAI) and GEN that naturally exists in soy protein-based infant formula results in greater benefits to bone at adulthood than either...
متن کاملProtective effects of prepubertal genistein exposure on mammary tumorigenesis are dependent on BRCA1 expression.
This study investigated whether prepubertal dietary exposure to genistein reduces mammary tumorigenesis by upregulating Brca1 expression in mice. Heterozygous Brca1(+/-) mice and their wild-type (WT) littermates were fed control AIN93G diet or 500 ppm genistein-supplemented AIN93G diet from postnatal day (PND) 15 to PND30 and then switched to AIN93G diet. Prepubertal dietary exposure to geniste...
متن کاملAltered mammary gland development in male rats exposed to genistein and methoxychlor.
Genistein (GE) is a prevalent phytoestrogen whose presence in human and animal foods may affect biological actions of synthetic endocrine active compounds. We have previously reported that in utero and lactational exposure to high doses of GE or the endocrine active pesticide methoxychlor (MXC) caused mammary epithelial proliferation in 21-day-old male rats. Combined exposure to GE and MXC resu...
متن کاملPeripubertal exposure to male chemosignals accelerates vaginal opening and induces male-directed odor preference in female mice
Citation: Jouhanneau M, Goudet C, Moussu C, Tashiro T, Buatois B, Mori K, Ganem G and Keller M (2015) Peripubertal exposure to male chemosignals accelerates vaginal opening and induces male-directed odor preference in female mice. Front. Ecol. Evol. 3:34. doi: 10.3389/fevo.2015.00034 Peripubertal exposure to male chemosignals accelerates vaginal opening and induces male-directed odor preference...
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ژورنال
عنوان ژورنال: Reproductive Toxicology
سال: 2015
ISSN: 0890-6238
DOI: 10.1016/j.reprotox.2014.10.023